【Technical News】Congratulations to our technical team on the successful delivery of the following synthetic technology projects to our foreign customers

31 Jul.,2025

We have a highly qualified R&D and production team with more than 20 years of experience incustom synthesis, focusing on providing customers with innovative solutions and customized products.In recent years, we continue to strengthen the research and innovation of production technology, toprovide efficient and high-quality services.

 

Product 1:

【1】Product Backgroud

Product name Hypericin
Cas no. 548-04-9
Molecular formula C30H16O8
Molecular weight 504.44
Melting point 299-301°C
Storage condition -20°C

【2】Technical data

✓ It has a conjugated polycyclic aromatic hydrocarbon structure and contains multiple hydroxyl groups, which endow it with photosensitivity and antioxidant activity

✓ Purity can reach more than 98%

【3】Technological advantage

✓ Suitable for mg to gram magnification

✓ The synthesis process is mature

【4】Commercial application

1. Medical field:
Antiviral drugs (such as those studied for herpes virus), antidepressant adjunctive therapies (extracts of Forsythia suspensa).
Photodynamic therapy for tumors or local infections.
2. Agricultural field:
Used as a natural antibacterial agent in animal feed additives (phototoxicity should be noted)
3. Research Tools:
Fluorescent probes (due to strong red fluorescence), used for cell imaging

Product 2:

【1】 Product background

Product name Alvespimycin
Cas no. 467214-20-6
Molecular formula C32H48N4O8
Molecular weight 616.75
Storage condition Desiccate at -20°C
Melting point >270°C

【2】Technical data

✓ It consists of three parts:
The iron carrier part (similar to iron pigments, such as deferriamine) : responsible for chelating iron ions (Fe³⁺).
Antibiotic components (thiopeptides or nucleosides) : They function by inhibiting bacterial protein synthesis.
Connecting bridge: Covalently combine iron carriers with antibiotics

✓ Purity can reach more than 98%

【3】Technological advantage

✓ Suitable for mg to gram magnification

✓ The synthesis process is mature

【4】Commercial application

1.Hospital drug-resistant infections: Salvage treatment of carbapenem-resistant Enterobacter (CRE).
2.Animal husbandry: Replace banned antibiotics (such as growth promoters) to reduce the spread of drug resistance

Product 3:

【1】 Product background

Product name (2R,3R,4S,5S,6R)-2-(4-chloro-3-(4-ethoxybenzyl)phenyl)-6-(hydroxymethyl)-2-methoxytetrahydro-2H-pyran-3,4,5-triol
Molecular formula C₂₂H₂₇ClO₇
Molecular weight 438.90
Product attributes It belongs to dapagliflozin impurity products

【2】Technical data

✓ Core skeleton:
Glucoside analogues: Pyran ring (tetrahydro-2H-pyran) structure, containing multiple chiral centers (2R,3R,4S,5S,6R).
✓ Substituent:
1.4-chloro-3 -(4-ethoxy benzyl) phenyl: Hydrophobic aromatic ring, which may affect target binding.
2.Methoxy (2-OCH₃) : Enhances metabolic stability.
3.Hydroxymethyl (6-CH₂OH) : Provides polarity and may be involved in hydrogen bond interactions. Product attributes

✓ Purity can reach more than 98%

【3】Technological advantage

✓ Suitable for mg to gram magnification

✓ The synthesis process is mature

【4】Commercial application

1.Drug development
Targeted hypoglycemic drugs: With structural characteristics similar to SGLT-2 inhibitors (such as empagliflozin), they may be used in the treatment of diabetes (the inhibitory activity against sodium-glucose cotransporter needs to be verified).
Anti-inflammatory or anti-tumor: Aryl chloride and ethoxy benzyl structures are commonly found in anti-inflammatory/anti-cancer molecules (such as COX-2 inhibitor analogues).
2. Intermediates or prodrugs
Synthetic intermediates: used for constructing more complex glycoside compounds.
Prodrug design: Hydroxymethyl groups can be derivatized (such as esterified) to improve oral absorption.

Product 4:

【1】 Product background

Product name AMAROGENTIN
Cas no. 21018-84-8
Molecular formula C29H30O13
Molecular weight 586.54
Melting point 229-230°
Boiling point 928.5±65.0 °C
Optical rotation D20 -116.6°

【2】Technical data

✓ 1. Core structure:
Secoiridoid aglycone
Glycoside part: Glucose (β-D-glucopyranosyl)
Esterification group: Benzoyl
✓ 2. Structural Features:
It has a highly bitter taste (more than 1,000 times that of quinine).
Containing multiple chiral centers, the three-dimensional configuration affects biological activity

✓ Purity can reach more than 97%

【3】Technological advantage

✓ Suitable for mg to gram magnification

✓ The synthesis process is mature

【4】Commercial application

1. Pharmaceutical industry
Digestive system medications (such as stomach-relieving and digestive tablets, bitter stomach-relieving agents)
Liver-protecting drugs (for combating alcoholic liver injury)
2. Food Industry:
Bittering agent (for beer and bitter beverages)
3. Cosmetics Industry:
Anti-inflammatory ingredients (used in soothing skin care products)